Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 18/20 | 0.68 |
| ▸ | ACE | P12821 | 9/20 | 0.68 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.58 |
| ▸ | MMEL1 | Q495T6 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16008601 | 1.00 | MME (0.68) | MMEACEGPR34MMEL1 | |
| SCHEMBL16008132 | 0.92 | MME (0.74) | MMEACEGPR34MMEL1 | |
| SCHEMBL16009025 | 0.88 | MME (0.77) | MMEACEMMEL1 | |
| SCHEMBL16008325 | 0.87 | MME (0.70) | MMEACEGPR34MMEL1 | |
| SCHEMBL16011784 | 0.87 | MME (0.70) | MMEACEGPR34MMEL1 | |
| SCHEMBL16008666 | 0.86 | MME (0.66) | MMEACEGPR34MMEL1 | |
| SCHEMBL19582914 | 0.84 | MME (0.74) | MMEACEMMEL1 | |
| SCHEMBL16008324 | 0.84 | MME (0.74) | MMEACEMMEL1 | |
| SCHEMBL16009111 | 0.84 | MME (0.74) | MMEACEMMEL1 | |
| SCHEMBL23055194 | 0.83 | MME (0.73) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9428457-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2016-08-30 | — | — | US | claimed |