Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.65 |
| ▸ | NQO2 | P16083 | 4/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27511729 | 0.98 | TLR8 (0.62) | TLR8NQO2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL27652636 | 0.93 | TLR8 (0.57) | TLR8NQO2PDGFRBPDGFRAALDH1A1 | |
| Quinoline SCHEMBL28250283 | 0.88 | PDGFRB (0.63) | TLR8NQO2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL27530598 | 0.86 | TLR8 (0.50) | TLR8NQO2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL30989199 | 0.83 | TLR8 (0.50) | TLR8NQO2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL14280967 | 0.83 | TLR8 (0.50) | TLR8NQO2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL18023061 | 0.82 | TLR8 (0.49) | TLR8NQO2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL9590284 | 0.82 | TLR8 (0.67) | TLR8NQO2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL6567448 | 0.81 | TLR8 (0.53) | TLR8NQO2PDGFRBPDGFRAALDH1A1 | |
| SCHEMBL11167917 | 0.81 | TLR8 (0.49) | TLR8NQO2ALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 368 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111574443-A | Preparation method for degrading and removing para-fluoroaniline impurities by cabozantinib | 廊坊市泽康医药科技有限公司 | 2020-08-25 | — | — | CN | claimed |
| CN-111533690-A | Preparation method of cabozantinib defluorinated impurity | 廊坊市泽康医药科技有限公司 | 2020-08-14 | — | — | CN | claimed |
| CN-111518027-A | Preparation method of cabozantinib nitrogen oxide impurity | 廊坊市泽康医药科技有限公司 | 2020-08-11 | — | — | CN | claimed |
| CN-111423371-A | Synthesis method of cabozantinib dimer | 廊坊市泽康医药科技有限公司 | 2020-07-17 | — | — | CN | claimed |
| CN-110283165-A | 4- phenoxyquinolines and alpha-acyloxy amides compound and its preparation method and application | 哈尔滨工业大学（威海） | 2019-09-27 | — | — | CN | claimed |
| CN-108658856-A | A kind of catalyzed by solid base prepares antitumor drug card and praises for the method for Buddhist nun's intermediate | 张淑华 | 2018-10-16 | — | — | CN | claimed |
| CN-108525684-A | A kind of preparation method of antineoplastic target medicine tivozanib intermediates | 孙金霞 | 2018-09-14 | — | — | CN | claimed |
| CN-108083599-A | For the foam Ti-base catalyst of sludge hot hydrolysis process system | 北京达源环保科技有限公司 | 2018-05-29 | — | — | CN | claimed |
| CN-107879583-A | Sludge pyrohydrolysis and anaerobic digestion integrated treatment process system | 北京达源环保科技有限公司 | 2018-04-06 | — | — | CN | claimed |
| CN-105541798-B | Quinolines Mutiple Targets kinase inhibitor with antitumor activity and preparation method thereof | 中国人民解放军第二军医大学 | 2018-01-23 | — | — | CN | claimed |
| WO-2009118327-A1 | 1,4-NAPHTHOQUINONE DERIVATIVES AND THERAPEUTIC USE THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-10-01 | — | — | WO | claimed |
| CN-101293869-A | Quinoline and quinoxaline compounds which inhibit platelet-derived growth factor and/or p561lck tyrosine kinases | AVENTIS PHARM PROD INC (US) | 2008-10-29 | — | — | CN | claimed |
| CN-100390154-C | Quinoline and quinoxaline compounds as PDGF-receptor and/or LCK tyrosine kinase inhibitors | AVENTIS PHARM PROD INC (GB) | 2008-05-28 | — | — | CN | claimed |
| CN-1252054-C | Qinoline derivatives inhibiting effect of growth factors such as VEGF | ZENECA LTD (GB) | 2006-04-19 | — | — | CN | claimed |
| WO-2005087742-A1 | METABOLIC KINASE MODULATORS AND METHODS OF USE AS PESTICIDES | EXELIXIS, INC. (US) | 2005-09-22 | — | — | WO | claimed |
| CN-1158266-C | Chemical compounds | — | 2004-07-21 | — | — | CN | claimed |
| CN-1342150-A | Quinoline and quinoxaline compounds as PDGF-receptor and/or LCK tyrosine kinase inhibitors | AVENTIS PHARM PROD INC (US) | 2002-03-27 | — | — | CN | claimed |
| CN-1321151-A | Chemical compounds | ASTRAZENECA AB (SE) | 2001-11-07 | — | — | CN | claimed |
| CN-1261353-A | Inhibition of platelet-derived growth factor and/or p56lckQuinoline and quinoxaline compounds of tyrosine kinases | RHONE POULENC RORER PHARMA (US) | 2000-07-26 | — | — | CN | claimed |
| CN-1198158-A | Bicyclic 4-aralkylaminopyrimidine derivatives as tyrosine kinase inhibitors | PHARMACIA & UPJOHN SPA (IT) | 1998-11-04 | — | — | CN | claimed |