Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | FABP1 | P07148 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 1/20 | 0.35 |
| ▸ | CTRC | Q99895 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2522034 | 0.84 | FABP1 (0.48) | CYP1A2ERBB2FYNMAOAACHE | |
| SCHEMBL5720268 | 0.81 | FABP1 (0.46) | CYP1A2ERBB2FYNMAOAACHE | |
| SCHEMBL12486529 | 0.76 | CYP1A2 (0.59) | CYP1A2ERBB2FYNMAOAACHE | |
| SCHEMBL6264675 | 0.75 | CYP1A2 (0.87) | CYP1A2ERBB2FYNMAOAACHE | |
| SCHEMBL29746490 | 0.75 | CYP1A2 (0.86) | CYP1A2ERBB2FYNMAOAACHE | |
| SCHEMBL1096241 | 0.75 | CYP1A2 (0.86) | CYP1A2ERBB2FYNMAOAACHE | |
| SCHEMBL1288207 | 0.75 | CYP1A2 (0.86) | CYP1A2ERBB2FYNMAOAACHE | |
| SCHEMBL30122951 | 0.75 | CYP1A2 (0.86) | CYP1A2ERBB2FYNMAOAACHE | |
| Phosphine SCHEMBL3821605 | 0.75 | FABP1 (0.52) | CYP1A2ERBB2FYNMAOAACHE | |
| SCHEMBL27494241 | 0.74 | FABP1 (0.48) | CYP1A2FABP1SLC22A6ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10975079-B2 | 4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives for use as BCRP inhibitors in therapeutic treatments | SCANDION ONCOLOGY A/S (DK) | 2021-04-13 | — | — | US | disclosed |
| US-20180044341-A1 | 4-AMINO-3-PHENYLAMINO-6-PHENYLPYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES FOR USE AS BCRP INHIBITORS IN THERAPEUTIC TREATMENTS | DRITTE PATENTPORTFOLIO BETEILIGUNGS-GESELLSCHAFT MBH & CO. KG (DE) | 2018-02-15 | — | — | US | disclosed |
| EP-3064207-B1 | 4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives for use as BCRP inhibitors in therapeutic treatments | SCANDION ONCOLOGY AS (DK) | 2017-12-20 | — | — | EP | disclosed |
| EP-3064207-A1 | 4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives for use as BCRP inhibitors in therapeutic treatments | Dritte Patentportfolio Beteiligungsgesellschaft mbH & Co. KG (DE) | 2016-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044341-A1 | 4-AMINO-3-PHENYLAMINO-6-PHENYLPYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES FOR USE AS BCRP INHIBITORS IN THERAPEUTIC TREATMENTS | ABCB1, ABCC1, MPHOSPH6 | CYP1A2 1108/4885ERBB2 1905/4885FYN 2823/4885 |
| US-10975079-B2 | 4-amino-3-phenylamino-6-phenylpyrazolo[3,4-d]pyrimidine derivatives for use as BCRP inhibitors in therapeutic treatments | ABCB1, ABCC1, MPHOSPH6 | CYP1A2 1108/4885ERBB2 1905/4885FYN 2823/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.