Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 19/20 | 0.83 |
| ▸ | KCNJ1 | P48048 | 13/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14790188 | 0.91 | KCNH2 (1.00) | KCNH2KCNJ1 | |
| SCHEMBL14790715 | 0.89 | KCNH2 (0.83) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL14790420 | 0.89 | KCNH2 (0.83) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL4549601 | 0.88 | KCNH2 (1.00) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL14790700 | 0.82 | KCNH2 (1.00) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL4549287 | 0.82 | KCNH2 (0.90) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL14785779 | 0.79 | KCNH2 (0.86) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL4549594 | 0.78 | KCNH2 (1.00) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL4549583 | 0.78 | KCNH2 (1.00) | KCNH2KCNJ1SLC6A4 | |
| SCHEMBL14786579 | 0.77 | KCNH2 (0.71) | KCNH2KCNJ1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2755656-B1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME (US) | 2016-09-07 | — | — | EP | claimed |