Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 16/20 | 0.71 |
| ▸ | CDK9 | P50750 | 16/20 | 0.71 |
| ▸ | CCNH | P51946 | 16/20 | 0.71 |
| ▸ | CCNK | O75909 | 15/20 | 0.71 |
| ▸ | CDK12 | Q9NYV4 | 15/20 | 0.71 |
| ▸ | CCNT1 | O60563 | 14/20 | 0.71 |
| ▸ | CDK2 | P24941 | 14/20 | 0.71 |
| ▸ | CDK13 | Q14004 | 12/20 | 0.71 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.71 |
| ▸ | MNAT1 | P51948 | 12/20 | 0.67 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.67 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.65 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.64 |
| ▸ | CDK1 | P06493 | 2/20 | 0.64 |
| ▸ | CDK8 | P49336 | 1/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.64 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.64 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.64 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.64 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16665625 | 1.00 | CDK7 (0.71) | CDK7CDK9CCNHCCNKCDK12 | |
| SCHEMBL16655414 | 0.94 | CDK7 (0.79) | CDK7CDK9CCNHCCNKCDK12 | |
| SCHEMBL16655417 | 0.94 | CDK7 (0.79) | CDK7CDK9CCNHCCNKCDK12 | |
| SCHEMBL16655094 | 0.90 | CDK7 (0.81) | CDK7CDK9CCNHCCNKCDK12 | |
| SCHEMBL16655097 | 0.90 | CDK7 (0.81) | CDK7CDK9CCNHCCNKCDK12 | |
| SCHEMBL16655098 | 0.90 | CDK7 (0.81) | CDK7CDK9CCNHCCNKCDK12 | |
| SCHEMBL16655091 | 0.90 | CDK7 (0.81) | CDK7CDK9CCNHCCNKCDK12 | |
| SCHEMBL21397480 | 0.90 | CDK2 (0.59) | CDK7CDK9CCNHCCNKCDK12 | |
| SCHEMBL18078674 | 0.89 | CDK2 (0.67) | CDK7CDK9CCNHCCNKCDK12 | |
| SCHEMBL16655887 | 0.89 | CDK2 (0.63) | CDK7CDK9CCNHCCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190292167-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2019-09-26 | — | — | US | disclosed |
| US-20160264552-A1 | HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190292167-A1 | HETEROAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES | CDK7, CDK3, CDK17 | CDK7 1/4885CDK9 8/4885CCNH 32/4885 |
| US-20160264552-A1 | HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | CDK7, CDK6, CDK3 | CDK7 1/4885CDK9 12/4885CCNH 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.