Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 14/20 | 0.38 |
| ▸ | MAPK3 | P27361 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | MMP1 | P03956 | 1/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28518430 | 1.00 | SYK (0.38) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL20703386 | 0.86 | SYK (0.34) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL14332451 | 0.85 | SYK (0.34) | SYKMAPK3MAPK1KCNH2AURKB | |
| Hydrochloric Acid SCHEMBL20959415 | 0.83 | SYK (0.34) | SYKKCNH2AURKBMMP2MMP9 | |
| SCHEMBL18048136 | 0.82 | CHRM1 (0.30) | — | |
| SCHEMBL16059434 | 0.82 | GABRR1 (0.36) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL16059783 | 0.82 | GABRR1 (0.36) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL17820639 | 0.82 | GABRR1 (0.36) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL17838820 | 0.82 | GABRR1 (0.36) | SYKMAPK3MAPK1KCNH2AURKB | |
| SCHEMBL20331134 | 0.79 | FGFR4 (0.38) | SYKMAPK3MAPK1KCNH2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10155765-B2 | Carboxamide inhibitors of IRAK4 activity | MERCK SHARP & DOHME CORP. (US) | 2018-12-18 | — | — | US | disclosed |
| US-20180051027-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2018-02-22 | — | — | US | disclosed |
| EP-3268367-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2018-01-17 | — | — | EP | disclosed |
| WO-2016144844-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2016-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180051027-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | IRAK4, IRAK2, IRAK1 | SYK 355/4885MAPK3 883/4885MAPK1 704/4885 |
| US-10155765-B2 | Carboxamide inhibitors of IRAK4 activity | IRAK4, IRAK2, IRAK1 | SYK 355/4885MAPK3 883/4885MAPK1 704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.