Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 13/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.34 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13893589 | 0.89 | CHEK1 (0.40) | CHEK1CHEK2 | |
| SCHEMBL617330 | 0.83 | CHEK1 (0.61) | CHEK1CHEK2 | |
| SCHEMBL10221418 | 0.78 | CHEK1 (0.46) | CHEK1CHEK2KCNH2 | |
| SCHEMBL18052225 | 0.78 | CHEK1 (0.39) | CHEK1CHEK2NSD2EHMT2IKBKE | |
| SCHEMBL12123022 | 0.78 | CHEK1 (0.51) | CHEK1CHEK2 | |
| SCHEMBL617318 | 0.76 | CHEK1 (0.57) | CHEK1CHEK2KCNH2 | |
| SCHEMBL617465 | 0.74 | CHEK1 (0.66) | CHEK1CHEK2 | |
| SCHEMBL618516 | 0.73 | CHEK1 (0.62) | CHEK1CHEK2 | |
| SCHEMBL13893599 | 0.70 | CHEK1 (0.42) | CHEK1CHEK2EHMT2PRKCQ | |
| SCHEMBL12123024 | 0.70 | CHEK1 (0.47) | CHEK1CHEK2PRKCQKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197874-B1 | PYRAZIN-2-YL-PYRIDIN-2-YL-AMINE AND PYRAZIN-2-YL-PYRIMIDIN-4-YL-AMINE COMPOUNDS AND THEIR USE | CANCER REC TECH LTD (GB) | 2016-08-31 | — | — | EP | disclosed |