Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.37 |
| ▸ | KDM5A | P29375 | 6/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 3/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39648 | 0.86 | SLC34A2 (0.44) | KDM4CKDM5AKDM5BKDM4EMEN1 | |
| SCHEMBL40138 | 0.80 | SLC34A2 (0.42) | KDM4CKDM5BKDM4EMEN1ALDH1A1 | |
| SCHEMBL40191 | 0.80 | SLC34A2 (0.42) | MEN1ALDH1A1KMT2ATP53MAPT | |
| SCHEMBL46664 | 0.77 | SLC34A2 (0.49) | MAPT | |
| SCHEMBL18059177 | 0.77 | SLC34A2 (0.46) | KDM4CKDM4E | |
| SCHEMBL39885 | 0.76 | SLC34A2 (0.48) | MEN1KMT2AALK | |
| SCHEMBL40026 | 0.76 | KDM1A (0.47) | ALK | |
| SCHEMBL39707 | 0.76 | SLC34A2 (0.58) | KDM4E | |
| SCHEMBL39971 | 0.75 | SLC34A2 (0.59) | KDM4E | |
| SCHEMBL44858 | 0.74 | SLC34A2 (0.45) | ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |