Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 8/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | HPGD | P15428 | 4/20 | 0.70 |
| ▸ | CUL4A | Q13619 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 2/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.51 |
| ▸ | CBFB | Q13951 | 1/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17351326 | 0.86 | PDE9A (0.74) | PDE9AALDH1A1HPGDCUL4AMEN1 | |
| SCHEMBL17351484 | 0.85 | PDE9A (0.76) | PDE9AALDH1A1HPGDCUL4AMEN1 | |
| SCHEMBL15573916 | 0.84 | PDE9A (0.63) | PDE9AALDH1A1HPGDCUL4AMEN1 | |
| SCHEMBL17351400 | 0.84 | PDE9A (0.70) | PDE9AALDH1A1HPGDCUL4AMEN1 | |
| SCHEMBL17351455 | 0.83 | PDE9A (0.65) | PDE9AALDH1A1HPGDCUL4AMEN1 | |
| SCHEMBL17351291 | 0.83 | PDE9A (0.65) | PDE9AALDH1A1HPGDCUL4AMEN1 | |
| SCHEMBL19953000 | 0.82 | PDE9A (0.71) | PDE9AALDH1A1HPGDCUL4AMEN1 | |
| SCHEMBL17351501 | 0.82 | PDE9A (0.67) | PDE9AALDH1A1HPGDCUL4AMEN1 | |
| SCHEMBL18719837 | 0.81 | PDE9A (0.73) | PDE9AALDH1A1HPGDCUL4AMEN1 | |
| SCHEMBL18060129 | 0.81 | PDE9A (0.53) | PDE9AALDH1A1HPGDCUL4AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9562052-B2 | Bicyclicpyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-02-07 | — | — | US | disclosed |
| US-9562052-B2 | Bicyclicpyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2017-02-07 | — | — | US | disclosed |
| EP-2888245-B1 | NEW BICYCLICPYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-09-21 | — | — | EP | disclosed |
| EP-2888245-B1 | NEW BICYCLICPYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2016-09-21 | — | — | EP | disclosed |