Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1806310 | 0.81 | GUCY1A1 (0.37) | OPRL1 | |
| SCHEMBL1813166 | 0.76 | OPRL1 (0.49) | OPRL1NPC1RAB9A | |
| SCHEMBL11972707 | 0.75 | OPRL1 (0.39) | OPRL1P2RX7 | |
| SCHEMBL27871912 | 0.74 | OPRL1 (0.40) | OPRL1TSHRP2RX7NPC1RAB9A | |
| SCHEMBL1808960 | 0.74 | OPRL1 (0.42) | OPRL1TSHRNPC1RAB9A | |
| SCHEMBL1810586 | 0.71 | OPRL1 (0.37) | OPRL1 | |
| SCHEMBL11972686 | 0.71 | OPRL1 (0.40) | OPRL1NPC1RAB9A | |
| SCHEMBL11972841 | 0.70 | OPRL1 (0.41) | OPRL1RAB9A | |
| SCHEMBL27888227 | 0.70 | OPRL1 (0.42) | OPRL1 | |
| SCHEMBL22699130 | 0.69 | NCEH1 (0.54) | NCEH1TSHRBCHEACHEPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501704-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | Eli Lilly and Company (US) | 2012-09-26 | — | — | EP | disclosed |
| CN-102666550-A | Spiropiperidine compounds as ORL-1 receptor antagonists | LILLY CO ELI | 2012-09-12 | — | — | CN | disclosed |
| WO-2011060217-A1 | SPIROPIPERIDINE COMPOUNDS AS ORL-1 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |