Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.43 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.34 |
| ▸ | GABRD | O14764 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Threonine SCHEMBL5983520 | 1.00 | SLC7A5 (0.43) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Threonine SCHEMBL1537459 | 0.92 | SLC7A5 (0.50) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Threonine SCHEMBL8005616 | 0.92 | SLC7A5 (0.50) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Threonine SCHEMBL442280 | 0.92 | SLC7A5 (0.50) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Threonine SCHEMBL442279 | 0.92 | SLC7A5 (0.50) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Threonine SCHEMBL2765875 | 0.92 | SLC7A5 (0.50) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Threonine SCHEMBL1514090 | 0.92 | SLC7A5 (0.50) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Threonine SCHEMBL18729492 | 0.92 | SLC7A5 (0.50) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Threonine SCHEMBL1675354 | 0.92 | SLC7A5 (0.50) | SLC7A5GLRA1SLC6A9OR51E2SLC1A3 | |
| Threonine SCHEMBL22264058 | 0.89 | SLC7A5 (0.52) | SLC7A5SLC1A3SLC1A2SLC1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170130248-A1 | Byosynthetic Production of Acyl Amino Acids | EVONIK DEGUSSA GMBH (DE) | 2017-05-11 | — | — | US | disclosed |
| US-20160272950-A1 | METHOD FOR PRODUCING ACYL AMINO ACIDS | EVONIK DEGUSSA GMBH (DE) | 2016-09-22 | — | — | US | disclosed |