Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.63 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | FADS1 | O60427 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18048936 | 0.88 | KDR (0.61) | KDRMEN1KMT2AMAPTKDM4E | |
| SCHEMBL18048978 | 0.88 | KDR (0.63) | KDRGRM4MEN1KMT2AMAPT | |
| SCHEMBL18070968 | 0.85 | RXFP1 (0.64) | KDRMEN1KMT2AMAPTKDM4E | |
| SCHEMBL5755786 | 0.82 | KDR (0.57) | KDRGRM4HDAC6MEN1KMT2A | |
| SCHEMBL18049021 | 0.82 | KMT2A (0.60) | KDRMEN1KMT2AMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL5760682 | 0.82 | KDR (0.56) | KDRGRM4HDAC6MEN1KMT2A | |
| SCHEMBL18070938 | 0.81 | MEN1 (0.50) | KDRMEN1KMT2AMAPTKDM4E | |
| SCHEMBL18049826 | 0.79 | EGLN1 (0.51) | KDRMEN1KMT2AMAPTKDM4E | |
| SCHEMBL18048967 | 0.79 | KDR (0.64) | KDRMEN1KMT2AMAPTKDM4E | |
| SCHEMBL18070908 | 0.78 | KDR (0.49) | KDRGRM4MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |