Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18048967 | 0.87 | KDR (0.64) | KDRTRPV1GAAPTGS1MEN1 | |
| SCHEMBL18070968 | 0.82 | RXFP1 (0.64) | KDRHIF1APTGS1MEN1ALDH1A1 | |
| SCHEMBL18049845 | 0.80 | KDR (0.48) | KDRTRPV1GAAMEN1ALDH1A1 | |
| SCHEMBL18070967 | 0.80 | KDR (0.60) | KDRMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL18048976 | 0.78 | KDR (0.58) | KDRMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL18049021 | 0.77 | KMT2A (0.60) | KDRGAAMEN1ALDH1A1LMNA | |
| SCHEMBL18048936 | 0.77 | KDR (0.61) | KDRGAAMEN1ALDH1A1LMNA | |
| SCHEMBL18048926 | 0.77 | KDR (0.62) | KDRTRPV1GAAPTGS1MEN1 | |
| SCHEMBL18048989 | 0.77 | KDR (0.62) | KDRGAAMEN1ALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL18049016 | 0.77 | KDR (0.56) | KDRGAAMEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |
| WO-2016144792-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |