Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | FLT1 | P17948 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18048937 | 1.00 | MAPT (0.48) | MAPTKDRFLT1AXLFLT3 | |
| SCHEMBL18070929 | 1.00 | MAPT (0.48) | MAPTKDRFLT1AXLFLT3 | |
| SCHEMBL18070893 | 0.98 | MAPT (0.48) | MAPTKDRFLT1AXLFLT3 | |
| SCHEMBL18048941 | 0.98 | MAPT (0.48) | MAPTKDRFLT1AXLFLT3 | |
| SCHEMBL18070898 | 0.98 | MAPT (0.48) | MAPTKDRFLT1AXLFLT3 | |
| SCHEMBL18070977 | 0.87 | USP30 (0.39) | IDO1TDO2KMT2A | |
| SCHEMBL18049022 | 0.87 | USP30 (0.39) | IDO1TDO2KMT2A | |
| SCHEMBL18070934 | 0.87 | USP30 (0.39) | IDO1TDO2KMT2A | |
| SCHEMBL18070885 | 0.86 | KDR (0.61) | MAPTKDRAXLFLT3TYRO3 | |
| SCHEMBL18070882 | 0.86 | KDR (0.61) | MAPTKDRAXLFLT3TYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016144797-A1 | ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ALLOSTERIC MODULATORS, THEIR DERIVATIVES AND USES THEREOF | ALPHARMAGEN, LLC (US) | 2016-09-15 | — | — | WO | disclosed |