Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 20/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 16/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 3/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14649536 | 0.94 | PIK3CG (0.45) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3CA | |
| SCHEMBL14649521 | 0.93 | PIK3CG (0.45) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3CA | |
| SCHEMBL14667073 | 0.88 | PIK3CG (0.41) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3CA | |
| SCHEMBL14649485 | 0.88 | PIK3CG (0.46) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3CA | |
| SCHEMBL18074946 | 0.88 | PIK3CG (0.46) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3CA | |
| SCHEMBL14649374 | 0.88 | PIK3CG (0.41) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3CA | |
| SCHEMBL14649235 | 0.87 | PIK3CG (0.42) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3CA | |
| SCHEMBL14649373 | 0.86 | PIK3CG (0.48) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3CA | |
| SCHEMBL14649378 | 0.86 | PIK3CD (0.56) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3CA | |
| SCHEMBL14649114 | 0.85 | PIK3CG (0.45) | PIK3CGPIK3CDPIK3R1PIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734520-B1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | INFINITY PHARMACEUTICALS INC (US) | 2016-09-14 | — | — | EP | disclosed |