Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.68 |
| ▸ | CDK7 | P50613 | 11/20 | 0.66 |
| ▸ | CCNH | P51946 | 10/20 | 0.66 |
| ▸ | CDK1 | P06493 | 3/20 | 0.66 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.66 |
| ▸ | CDK2 | P24941 | 2/20 | 0.66 |
| ▸ | CDK9 | P50750 | 2/20 | 0.66 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.66 |
| ▸ | CDK8 | P49336 | 1/20 | 0.66 |
| ▸ | CDK13 | Q14004 | 2/20 | 0.65 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.65 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.65 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.65 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.65 |
| ▸ | CCNK | O75909 | 1/20 | 0.65 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.65 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.65 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.65 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29855866 | 0.94 | CDK7 (0.75) | EGFRCDK7CCNHCDK1CDK5 | |
| SCHEMBL20416128 | 0.94 | CDK7 (0.65) | EGFRCDK7CCNHCDK1CDK5 | |
| SCHEMBL18078648 | 0.89 | EGFR (0.69) | EGFRCDK7CCNHCDK1CDK5 | |
| SCHEMBL18078646 | 0.89 | EGFR (0.73) | EGFRCDK7CCNHCDK1CDK5 | |
| SCHEMBL20289038 | 0.88 | CDK7 (0.73) | EGFRCDK7CCNHCDK1CDK5 | |
| SCHEMBL18078675 | 0.86 | CDK7 (0.74) | EGFRCDK7CCNHCDK1CDK5 | |
| SCHEMBL18078641 | 0.86 | EGFR (0.75) | EGFRCDK7CCNHCDK1CDK5 | |
| SCHEMBL22143288 | 0.86 | CDK7 (0.75) | EGFRCDK7CCNHCDK1CDK5 | |
| SCHEMBL24900624 | 0.85 | CDK1 (0.62) | EGFRCDK7CCNHCDK1CDK5 | |
| SCHEMBL30221470 | 0.85 | CDK1 (0.62) | EGFRCDK7CCNHCDK1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200197392-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBEROUS SCLEROSIS COMPLEX | THE BRIGHAM & WOMEN'S HOSPITAL, INC. (US) | 2020-06-25 | — | — | US | disclosed |
| WO-2019035866-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBEROUS SCLEROSIS COMPLEX | THE BRIGHAM & WOMEN'S HOSPITAL, INC. (US) | 2019-02-21 | — | — | WO | disclosed |
| US-20160264552-A1 | HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | SYROS PHARMACEUTICALS INC (US) | 2016-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200197392-A1 | COMPOSITIONS AND METHODS FOR TREATING TUBEROUS SCLEROSIS COMPLEX | CDK7, CDK17, MTOR | EGFR 2279/4885CDK7 1/4885CCNH 16/4885 |
| US-20160264552-A1 | HETEROMAROMATIC COMPOUNDS USEFUL FOR THE TREATMENT OF PROLFERATIVE DISEASES | CDK7, CDK6, CDK3 | EGFR 3410/4885CDK7 1/4885CCNH 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.