Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HK1 | P19367 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29432616 | 0.81 | TEK (0.43) | LRRK2PIK3CDPIK3R1CYP2C19HSD17B10 | |
| SCHEMBL18079032 | 0.80 | PIK3CD (0.53) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL18079042 | 0.77 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3CBPIK3CA | |
| SCHEMBL18079008 | 0.77 | DDR2 (0.44) | PIK3CDHSD17B10PIK3CGCYP11B2LIMK1 | |
| SCHEMBL18079002 | 0.73 | PIK3CD (0.44) | LRRK2PIK3CDPIK3R1PIK3CGPIK3CB | |
| SCHEMBL18079025 | 0.73 | PIK3CD (0.55) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL18079001 | 0.72 | PIK3CD (0.60) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL17331681 | 0.70 | PIK3CD (0.44) | LRRK2PIK3CDPIK3R1PIK3CGPIK3CB | |
| SCHEMBL17331501 | 0.70 | PIK3CD (0.44) | LRRK2PIK3CDPIK3R1PIK3CGPIK3CB | |
| SCHEMBL18079041 | 0.70 | HSD17B10 (0.61) | CYP2C19HSD17B10SMN1; SMN2ALDH1A1HK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3266774-B1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE DELTA INHIBITOR AND USE THEREOF | NANJING SANHOME PHARMACEUTICAL CO LTD (CN) | 2019-09-04 | — | — | EP | disclosed |
| US-20180037576-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE DELTA INHIBITOR AND USE THEREOF | NANJING SANHOME PHARMACEUTICAL CO., LTD. (CN) | 2018-02-08 | — | — | US | disclosed |
| WO-2016141855-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE Δ INHIBITOR AND USE THEREOF | 南京圣和药业股份有限公司 | 2016-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180037576-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE DELTA INHIBITOR AND USE THEREOF | PIK3CA, PIK3CD, PIK3CB | LRRK2 1678/4885PIK3CD 2/4885PIK3R1 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.