Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.38 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24461460 | 0.90 | BCHE (0.41) | BCHEKDM4EKDM2BKAT2BMEN1 | |
| SCHEMBL12424240 | 0.90 | BCHE (0.41) | BCHEKDM4EKDM2BKAT2BMEN1 | |
| SCHEMBL3234907 | 0.86 | MAPT (0.42) | OGFRL1KDM4EHRH3KDM2BMEN1 | |
| SCHEMBL3234901 | 0.86 | MAPT (0.42) | OGFRL1KDM4EHRH3KDM2BMEN1 | |
| SCHEMBL17277355 | 0.84 | KDM4E (0.39) | BCHEKDM4EHRH3 | |
| SCHEMBL13102 | 0.81 | KDM4E (0.54) | KDM4EHRH3 | |
| SCHEMBL12449641 | 0.81 | KDM4E (0.54) | KDM4EHRH3 | |
| SCHEMBL18082565 | 0.80 | GBA1 (0.38) | KDM2BKAT2BMEN1KMT2A | |
| SCHEMBL12458880 | 0.80 | GBA1 (0.38) | KDM2BKAT2BMEN1KMT2A | |
| SCHEMBL18082571 | 0.79 | BCHE (0.37) | BCHEKDM2BKAT2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |