Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 5/20 | 0.62 |
| ▸ | PIK3R2 | O00459 | 5/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.62 |
| ▸ | PIK3R5 | Q8WYR1 | 5/20 | 0.62 |
| ▸ | PIK3R3 | Q92569 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 5/20 | 0.49 |
| ▸ | THRB | P10828 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7046 | 0.89 | PIK3CD (0.66) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7312 | 0.83 | PIK3CD (0.71) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7738 | 0.77 | PIK3CD (1.00) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7000 | 0.75 | PIK3CD (0.68) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12686 | 0.73 | PIK3CD (0.58) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7347 | 0.72 | TP53 (0.66) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7172 | 0.71 | PIK3CD (0.63) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12275777 | 0.69 | PIK3CD (0.63) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7240 | 0.69 | PIK3CD (0.75) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL19128204 | 0.69 | CCNA2 (0.54) | MAPTMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |