Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.67 |
| ▸ | PIK3R2 | O00459 | 19/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 19/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 19/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 19/20 | 0.67 |
| ▸ | PIK3R5 | Q8WYR1 | 19/20 | 0.67 |
| ▸ | PIK3R3 | Q92569 | 19/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7567 | 0.90 | PIK3CD (0.71) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7065 | 0.81 | PIK3CD (0.64) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7603 | 0.81 | PIK3CD (1.00) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL7170 | 0.74 | PIK3CD (0.71) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL18082825 | 0.73 | PIK3CD (0.67) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13261 | 0.70 | PIK3CD (0.67) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12449845 | 0.70 | PIK3CD (0.72) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL8229 | 0.70 | PIK3CD (0.71) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL8029 | 0.70 | PIK3CD (0.71) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL8335 | 0.70 | PIK3CD (0.71) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |