Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | CES1 | P23141 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18089635 | 0.84 | CA1 (0.59) | CA1CA2BCHEACHEHTT | |
| SCHEMBL8519322 | 0.83 | TSHR (0.53) | HTTTSHR | |
| SCHEMBL27364772 | 0.83 | AKR1C3 (0.68) | AKR1C3NPC1RAB9ACA1CA2 | |
| SCHEMBL18214656 | 0.83 | CA1 (0.54) | AKR1C3NPC1RAB9ACA1CA2 | |
| SCHEMBL6932050 | 0.82 | AKR1C3 (0.70) | AKR1C3NPC1RAB9ACA1CA2 | |
| SCHEMBL972717 | 0.80 | CA1 (0.67) | AKR1C3NPC1RAB9ACA1CA2 | |
| SCHEMBL22322100 | 0.77 | CA1 (0.54) | NPC1RAB9ACA1CA2BCHE | |
| SCHEMBL1809484 | 0.76 | NPC1 (0.50) | NPC1RAB9ACA1CA2CYP2C19 | |
| SCHEMBL2081746 | 0.76 | MAPT (0.71) | RAB9ACA1CA2HTTMAPT | |
| SCHEMBL13537855 | 0.75 | AKR1C3 (0.60) | AKR1C3NPC1RAB9AHTTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180105549-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2018-04-19 | — | — | US | disclosed |
| US-9828408-B2 | HCV polymerase inhibitors | MEDIVIR AB (SE) | 2017-11-28 | — | — | US | disclosed |
| US-20170107244-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2017-04-20 | — | — | US | disclosed |
| US-20160271160-A1 | HCV POLYMERASE INHIBITORS | MEDIVIR AB (SE) | 2016-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160271160-A1 | HCV POLYMERASE INHIBITORS | POLI, POLB, POLL | AKR1C3 1475/4885NPC1 761/4885RAB9A 2125/4885 |
| US-20170107244-A1 | HCV POLYMERASE INHIBITORS | POLI, POLB, POLL | AKR1C3 1475/4885NPC1 761/4885RAB9A 2125/4885 |
| US-20180105549-A1 | HCV POLYMERASE INHIBITORS | POLI, POLB, POLL | AKR1C3 1475/4885NPC1 761/4885RAB9A 2125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.