Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 19/20 | 0.52 |
| ▸ | PIK3R1 | P27986 | 19/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL950596 | 0.87 | PIK3CA (0.64) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL995298 | 0.86 | PIK3CA (0.67) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL947860 | 0.85 | PIK3CA (0.63) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL952126 | 0.84 | PIK3CA (0.64) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL950591 | 0.83 | PIK3CA (0.73) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL948177 | 0.78 | PIK3CA (0.79) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL947783 | 0.77 | PIK3CA (0.73) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL948407 | 0.77 | PIK3CA (0.76) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL946591 | 0.77 | PIK3CA (0.76) | PIK3CAPIK3CBPIK3CDPIK3R1 | |
| SCHEMBL950863 | 0.76 | PIK3CA (0.72) | PIK3CAPIK3CBPIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3072890-A1 | Pyrimidinyl and 1,3,5-triazinyl benzimidazoles and their use in cancer therapy | MEI Pharma, Inc. (US) | 2016-09-28 | — | — | EP | disclosed |