Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.75 |
| ▸ | TNNI3K | Q59H18 | 15/20 | 0.75 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1804731 | 0.86 | BRAF (0.67) | BRAFTNNI3KHRH3SRCKDR | |
| SCHEMBL6911431 | 0.86 | BRAF (1.00) | BRAFTNNI3KSRCKDR | |
| Hydrochloric Acid SCHEMBL1805208 | 0.86 | BRAF (0.98) | BRAFTNNI3KSRCKDR | |
| SCHEMBL6910959 | 0.77 | TNNI3K (0.85) | BRAFTNNI3K | |
| Hydrochloric Acid SCHEMBL12006441 | 0.76 | TNNI3K (0.84) | BRAFTNNI3K | |
| SCHEMBL6912894 | 0.75 | BRAF (0.77) | BRAFTNNI3KSRCKDREGFR | |
| SCHEMBL24777171 | 0.75 | TNNI3K (0.88) | BRAFTNNI3K | |
| SCHEMBL1810590 | 0.74 | TNNI3K (1.00) | BRAFTNNI3KSRCKDREGFR | |
| SCHEMBL1806419 | 0.74 | BRAF (0.64) | BRAFTNNI3KHRH3KDREGFR | |
| SCHEMBL29606885 | 0.74 | TNNI3K (0.85) | BRAFTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501233-A1 | QUINAZOLINE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-26 | — | — | EP | claimed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | claimed |
| EP-2501233-A1 | QUINAZOLINE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011056740-A1 | QUINAZOLINE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-12 | — | — | WO | disclosed |