Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 4/20 | 0.33 |
| ▸ | FPR2 | P25090 | 7/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2266059 | 1.00 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| SCHEMBL1411087 | 1.00 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| Bromide SCHEMBL1411151 | 0.99 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| Sulfuric Acid SCHEMBL1411685 | 0.96 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| Oxalic Acid SCHEMBL1411367 | 0.96 | PDE4D (0.46) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| Fumaric Acid SCHEMBL1410901 | 0.94 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| Fumaric Acid SCHEMBL1410897 | 0.94 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| Cadaverine Tartrate SCHEMBL1410963 | 0.94 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| Cadaverine Tartrate SCHEMBL1410960 | 0.94 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CPDE10A | |
| Alpha-Ketoglutaric Acid SCHEMBL1411183 | 0.92 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160279120-A1 | NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | TAKEDA GMBH (DE) | 2016-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160279120-A1 | NOVEL HYDROXY-6-HETEROARYLPHENANTHRIDINES AND THEIR USE AS PDE4 INHIBITORS | PDE4A, PDE12, PDE4B | PDE4D 5/4885PDE4A 1/4885PDE4B 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.