Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 6/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.41 |
| ▸ | BRD1 | O95696 | 1/20 | 0.41 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3915102 | 0.84 | PTGDR2 (0.48) | PTGDR2PKMMEN1KMT2AALDH1A1 | |
| SCHEMBL3913044 | 0.82 | BRD4 (0.46) | BRD4 | |
| SCHEMBL1814225 | 0.79 | PTGDR2 (0.46) | PTGDR2LMNABRD4MAPT | |
| SCHEMBL1809464 | 0.79 | PTGDR2 (0.49) | PTGDR2PKMMEN1KMT2AALDH1A1 | |
| SCHEMBL3913785 | 0.78 | PTGDR2 (0.48) | PTGDR2PKMMEN1KMT2AALDH1A1 | |
| SCHEMBL1811639 | 0.78 | PTGDR2 (0.48) | PTGDR2PKMMEN1KMT2AALDH1A1 | |
| SCHEMBL1812408 | 0.78 | MEN1 (0.46) | PTGDR2PKMMEN1KMT2AALDH1A1 | |
| SCHEMBL1821354 | 0.78 | BRD4 (0.59) | BRD4MAPTBRD1BRPF1 | |
| SCHEMBL5615200 | 0.78 | GSPT1 (0.47) | PKMMEN1KMT2ALMNABRD4 | |
| SCHEMBL3915082 | 0.77 | PTGDR2 (0.47) | PTGDR2PKMMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4682207-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| EP-1797042-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-20 | — | — | EP | claimed |
| WO-2006034804-A1 | INDOZOLONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-04-06 | — | — | WO | claimed |