Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT3A | Q9Y6K1 | 19/20 | 0.63 |
| ▸ | DNMT1 | P26358 | 10/20 | 0.61 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.49 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.49 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.49 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20109385 | 0.90 | DNMT3A (0.58) | DNMT3ANSD2EZH2EHMT2NSD3 | |
| SCHEMBL20109391 | 0.90 | DNMT3A (0.60) | DNMT3ANSD2EZH2EHMT2NSD3 | |
| SCHEMBL18095979 | 0.89 | DNMT3A (0.70) | DNMT3ANSD2EZH2EHMT2NSD3 | |
| SCHEMBL17994888 | 0.86 | DNMT3A (0.78) | DNMT3ADNMT1NSD2 | |
| SCHEMBL18103391 | 0.83 | DNMT3A (0.74) | DNMT3ANSD2EZH2EHMT2NSD3 | |
| SCHEMBL18095982 | 0.83 | DNMT3A (0.75) | DNMT3ADNMT1 | |
| Hydrochloric Acid SCHEMBL18095980 | 0.82 | DNMT3A (0.73) | DNMT3ANSD2EZH2EHMT2NSD3 | |
| SCHEMBL18103410 | 0.81 | DNMT3A (0.84) | DNMT3ANSD2EZH2EHMT2NSD3 | |
| SCHEMBL18103380 | 0.79 | DNMT3A (0.67) | DNMT3ANSD2EZH2EHMT2NSD3 | |
| SCHEMBL16585878 | 0.78 | DNMT3A (0.78) | DNMT3ADNMT1NSD2EHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10450299-B2 | Substituted quinazoline derivatives as DNA methyltransferase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2019-10-22 | — | — | US | disclosed |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-05-03 | — | — | US | disclosed |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-05-03 | — | — | US | disclosed |
| EP-3277676-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS DNA METHYLTRANSFERASE INHIBITORS | Pierre Fabre Médicament (FR) | 2018-02-07 | — | — | EP | disclosed |
| WO-2016151144-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS DNA METHYLTRANSFERASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2016-09-29 | — | — | WO | disclosed |
| WO-2016151144-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS DNA METHYLTRANSFERASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2016-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450299-B2 | Substituted quinazoline derivatives as DNA methyltransferase inhibitors | DNMT1, DNMT3A, DNMT3B | DNMT3A 2/4885DNMT1 1/4885NSD2 87/4885 |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | DNMT1, DNMT3A, DNMT3B | DNMT3A 2/4885DNMT1 1/4885NSD2 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.