Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Amlodipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 1/20 | 0.90 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.90 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.90 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.90 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.90 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.90 |
| ▸ | HTR1A | P08908 | 2/20 | 0.90 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.90 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.90 |
| ▸ | DRD1 | P21728 | 2/20 | 0.90 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.90 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.90 |
| ▸ | DRD3 | P35462 | 2/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.90 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.90 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.90 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.90 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.90 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.90 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271326 | 0.96 | TBXA2R (0.86) | TBXA2RADRA1ASLC6A3ABCB11ADORA3 | |
| SCHEMBL10833678 | 0.96 | TBXA2R (0.86) | TBXA2RADRA1ASLC6A3ABCB11ADORA3 | |
| Olradipine SCHEMBL30295459 | 0.95 | TBXA2R (0.83) | TBXA2RADRA1ASLC6A3ABCB11ADORA3 | |
| Olradipine SCHEMBL1344914 | 0.95 | TBXA2R (0.83) | TBXA2RADRA1ASLC6A3ABCB11ADORA3 | |
| Olradipine SCHEMBL9760698 | 0.95 | TBXA2R (0.83) | TBXA2RADRA1ASLC6A3ABCB11ADORA3 | |
| Olradipine SCHEMBL9760691 | 0.95 | TBXA2R (0.83) | TBXA2RADRA1ASLC6A3ABCB11ADORA3 | |
| Levamlodipine SCHEMBL30994756 | 0.95 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ABCB11ADORA3 | |
| Amlodipine SCHEMBL26478 | 0.95 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ABCB11ADORA3 | |
| Amlodipine SCHEMBL1816641 | 0.95 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ABCB11ADORA3 | |
| Amlodipine SCHEMBL29664887 | 0.95 | TBXA2R (1.00) | TBXA2RADRA1ASLC6A3ABCB11ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2322174-A2 | Combined use of valsartan and calcium channel blockers for therapeutic purposes | Novartis AG (CH) | 2011-05-18 | — | — | EP | claimed |
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |