Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.75 |
| ▸ | NAT1 | P18440 | 4/20 | 0.65 |
| ▸ | PTP4A3 | O75365 | 5/20 | 0.64 |
| ▸ | MMP2 | P08253 | 1/20 | 0.63 |
| ▸ | MMP3 | P08254 | 1/20 | 0.63 |
| ▸ | MMP13 | P45452 | 1/20 | 0.63 |
| ▸ | MMP14 | P50281 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 2/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12892144 | 1.00 | GSK3B (0.75) | GSK3BNAT1PTP4A3MMP2MMP3 | |
| SCHEMBL18102860 | 0.89 | GSK3B (0.73) | GSK3BNAT1PTP4A3MEN1KMT2A | |
| SCHEMBL18102906 | 0.88 | MEN1 (0.75) | GSK3BNAT1MMP2MMP3MMP13 | |
| SCHEMBL18102850 | 0.85 | MGAM (0.63) | GSK3BNAT1PTP4A3GAAPIM1 | |
| SCHEMBL18102974 | 0.85 | PTP4A3 (0.71) | GSK3BPTP4A3MEN1KMT2AALDH1A1 | |
| SCHEMBL18102903 | 0.84 | PDE4B (0.73) | GSK3BNAT1PTP4A3MEN1KMT2A | |
| SCHEMBL9025763 | 0.84 | GSK3B (0.54) | GSK3BNAT1PTP4A3MMP2MMP3 | |
| SCHEMBL9025766 | 0.84 | GSK3B (0.54) | GSK3BNAT1PTP4A3MMP2MMP3 | |
| SCHEMBL10090211 | 0.84 | PTP4A3 (0.83) | GSK3BNAT1PTP4A3MMP3MMP13 | |
| SCHEMBL18102857 | 0.84 | GSK3B (0.77) | GSK3BNAT1PTP4A3MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016154255-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | UNIVERSITY OF MIAMI (US) | 2016-09-29 | — | — | WO | disclosed |