Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAT1 | P18440 | 6/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | PIM1 | P11309 | 3/20 | 0.62 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | MYC | P01106 | 2/20 | 0.57 |
| ▸ | MAX | P61244 | 2/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.56 |
| ▸ | CRHBP | P24387 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.56 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3425971 | 0.88 | NAT1 (1.00) | NAT1TDP1PIM1PTP4A3GSK3B | |
| SCHEMBL3425968 | 0.88 | NAT1 (1.00) | NAT1TDP1PIM1PTP4A3GSK3B | |
| SCHEMBL15421702 | 0.88 | NAT1 (1.00) | NAT1TDP1PIM1PTP4A3GSK3B | |
| SCHEMBL18103029 | 0.86 | NAT1 (0.66) | NAT1PIM1PTP4A3GSK3BMYC | |
| SCHEMBL18095820 | 0.86 | NAT1 (0.66) | NAT1PIM1PTP4A3GSK3BMYC | |
| SCHEMBL18103052 | 0.86 | PIM1 (0.74) | NAT1PIM1PTP4A3GSK3BMYC | |
| SCHEMBL18102944 | 0.86 | PIM1 (0.74) | NAT1PIM1PTP4A3GSK3BMYC | |
| SCHEMBL18095819 | 0.86 | NAT1 (0.66) | NAT1PIM1PTP4A3GSK3BMYC | |
| SCHEMBL1449166 | 0.86 | NAT1 (0.74) | NAT1PIM1PTP4A3MYCMAX | |
| SCHEMBL18102951 | 0.86 | NAT1 (0.74) | NAT1PIM1PTP4A3GSK3BMYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016154255-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | UNIVERSITY OF MIAMI (US) | 2016-09-29 | — | — | WO | disclosed |