Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.87 |
| ▸ | MEN1 | O00255 | 6/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.79 |
| ▸ | POLB | P06746 | 3/20 | 0.79 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.79 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.73 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.69 |
| ▸ | GFER | P55789 | 2/20 | 0.68 |
| ▸ | CASP6 | P55212 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.67 |
| ▸ | TCF4 | P15884 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18102842 | 1.00 | AKR1B1 (0.87) | AKR1B1MEN1KMT2APOLBPTPN1 | |
| SCHEMBL10592653 | 0.96 | AKR1B1 (0.89) | AKR1B1MEN1KMT2APOLBPTPN1 | |
| SCHEMBL10492241 | 0.93 | AKR1B1 (0.85) | AKR1B1MEN1KMT2APOLBPTPN1 | |
| SCHEMBL10492234 | 0.93 | AKR1B1 (0.85) | AKR1B1MEN1KMT2APOLBPTPN1 | |
| SCHEMBL12008446 | 0.90 | CTNNB1 (0.77) | AKR1B1MEN1KMT2APOLBPTPN1 | |
| SCHEMBL19999083 | 0.89 | MEN1 (0.75) | AKR1B1MEN1KMT2APOLBPTPN1 | |
| SCHEMBL18102840 | 0.89 | AKR1B1 (0.76) | AKR1B1MEN1KMT2APOLBPTPN1 | |
| SCHEMBL19736251 | 0.88 | AKR1B1 (1.00) | AKR1B1MEN1KMT2APOLBPTPN1 | |
| SCHEMBL29408611 | 0.88 | AKR1B1 (1.00) | AKR1B1MEN1KMT2APOLBPTPN1 | |
| SCHEMBL6720207 | 0.88 | AKR1B1 (1.00) | AKR1B1MEN1KMT2APOLBPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016154255-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | UNIVERSITY OF MIAMI (US) | 2016-09-29 | — | — | WO | disclosed |