Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT3A | Q9Y6K1 | 13/20 | 0.58 |
| ▸ | DNMT1 | P26358 | 9/20 | 0.58 |
| ▸ | KMT5A | Q9NQR1 | 3/20 | 0.49 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.44 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.44 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30197579 | 1.00 | DNMT3A (0.58) | DNMT3ADNMT1KMT5AEHMT2KDM1A | |
| SCHEMBL18095979 | 0.87 | DNMT3A (0.70) | DNMT3AEHMT2KDM1ANSD2EZH2 | |
| SCHEMBL18103408 | 0.86 | KMT5A (0.57) | DNMT3AKMT5AEHMT2KDM1ARCOR1 | |
| Hydrochloric Acid SCHEMBL30197627 | 0.85 | KMT5A (0.56) | DNMT3AKMT5AEHMT2KDM1ARCOR1 | |
| SCHEMBL18103389 | 0.82 | KMT5A (0.52) | DNMT3AKMT5AEHMT2KDM1ARCOR1 | |
| SCHEMBL30197751 | 0.82 | EHMT2 (0.64) | DNMT3AKMT5AEHMT2KDM1ARCOR1 | |
| SCHEMBL18103392 | 0.82 | EHMT2 (0.64) | DNMT3AKMT5AEHMT2KDM1ARCOR1 | |
| SCHEMBL20109391 | 0.80 | DNMT3A (0.60) | DNMT3AEHMT2KDM1ANSD2EZH2 | |
| SCHEMBL20109385 | 0.78 | DNMT3A (0.58) | DNMT3AEHMT2KDM1ANSD2EZH2 | |
| SCHEMBL18095981 | 0.78 | DNMT3A (0.59) | DNMT3AKMT5AEHMT2KDM1ARCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10450299-B2 | Substituted quinazoline derivatives as DNA methyltransferase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2019-10-22 | — | — | US | disclosed |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-05-03 | — | — | US | disclosed |
| WO-2016151144-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AS DNA METHYLTRANSFERASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2016-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450299-B2 | Substituted quinazoline derivatives as DNA methyltransferase inhibitors | DNMT1, DNMT3A, DNMT3B | DNMT3A 2/4885DNMT1 1/4885KMT5A 28/4885 |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | DNMT1, DNMT3A, DNMT3B | DNMT3A 2/4885DNMT1 1/4885KMT5A 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.