Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.73 |
| ▸ | S1PR3 | Q99500 | 19/20 | 0.73 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.64 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.64 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12000582 | 1.00 | S1PR1 (0.73) | S1PR1S1PR3S1PR4S1PR5CYP2C8 | |
| SCHEMBL12000585 | 1.00 | S1PR1 (0.73) | S1PR1S1PR3S1PR4S1PR5CYP2C8 | |
| SCHEMBL11971371 | 1.00 | S1PR1 (0.73) | S1PR1S1PR3S1PR4S1PR5CYP2C8 | |
| SCHEMBL1810404 | 1.00 | S1PR1 (0.73) | S1PR1S1PR3S1PR4S1PR5CYP2C8 | |
| SCHEMBL12000586 | 0.92 | S1PR1 (0.62) | S1PR1S1PR3S1PR4S1PR5CYP2C8 | |
| SCHEMBL1815544 | 0.92 | S1PR1 (0.62) | S1PR1S1PR3S1PR4S1PR5CYP2C8 | |
| SCHEMBL1815549 | 0.92 | S1PR1 (0.62) | S1PR1S1PR3S1PR4S1PR5CYP2C8 | |
| SCHEMBL12000587 | 0.92 | S1PR1 (0.62) | S1PR1S1PR3S1PR4S1PR5CYP2C8 | |
| SCHEMBL14931555 | 0.85 | S1PR1 (0.58) | S1PR1S1PR3S1PR4S1PR5CYP2C8 | |
| SCHEMBL12000504 | 0.84 | S1PR1 (0.89) | S1PR1S1PR3S1PR4S1PR5CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493866-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | Bristol-Myers Squibb Company (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011059784-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |