Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.61 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.60 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.60 |
| ▸ | BRD4 | O60885 | 1/20 | 0.60 |
| ▸ | TNF | P01375 | 1/20 | 0.60 |
| ▸ | IL1B | P01584 | 1/20 | 0.60 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.60 |
| ▸ | MAP1LC3B | Q9GZQ8 | 4/20 | 0.57 |
| ▸ | STAT3 | P40763 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 7/20 | 0.55 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30241742 | 0.97 | CRBN (0.60) | CRBNIKZF1IKZF3BRD4TNF | |
| SCHEMBL30241745 | 0.97 | CRBN (0.60) | CRBNIKZF1IKZF3BRD4TNF | |
| SCHEMBL31276711 | 0.96 | CRBN (0.59) | CRBNIKZF1IKZF3BRD4TNF | |
| SCHEMBL31436690 | 0.96 | CRBN (0.59) | CRBNIKZF1IKZF3BRD4TNF | |
| SCHEMBL31436662 | 0.96 | CRBN (0.59) | CRBNIKZF1IKZF3BRD4TNF | |
| SCHEMBL16743005 | 0.92 | CRBN (0.61) | CRBNIKZF1IKZF3BRD4TNF | |
| SCHEMBL29856007 | 0.92 | CRBN (0.61) | CRBNIKZF1IKZF3BRD4TNF | |
| SCHEMBL31276564 | 0.90 | STAT3 (0.64) | CRBNIKZF1IKZF3BRD4TNF | |
| SCHEMBL18104081 | 0.90 | CRBN (0.58) | CRBNIKZF1IKZF3BRD4TNF | |
| SCHEMBL21333906 | 0.90 | CRBN (0.60) | CRBNIKZF1IKZF3BRD4TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160282354-A1 | COMPOSITIONS AND METHODS FOR SELECTING A TREATMENT FOR B-CELL NEOPLASIAS | THE BROAD INSTITUTE, INC. (US) | 2016-09-29 | — | — | US | disclosed |