SCHEMBL18106920

SCHEMBL18106920

O=C(O)CC(c1ccc(-c2ccc3cccnc3c2)cc1F)N1CCC2(CC1)CN(C1CC1)C(=O)CO2

nearest known ligand 0.59

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
FASN P49327 11/20 0.59
KDM1A O60341 1/20 0.35
GSK3B P49841 1/20 0.35
CHRNA7 P36544 2/20 0.33
MGLL Q99685 1/20 0.31
GPBAR1 Q8TDU6 1/20 0.31
HDAC3 O15379 1/20 0.31
HDAC4 P56524 1/20 0.31
HDAC1 Q13547 1/20 0.31
HDAC7 Q8WUI4 1/20 0.31
HDAC2 Q92769 1/20 0.31
HDAC10 Q969S8 1/20 0.31
HDAC11 Q96DB2 1/20 0.31
HDAC8 Q9BY41 1/20 0.31
HDAC6 Q9UBN7 1/20 0.31
HDAC9 Q9UKV0 1/20 0.31
HDAC5 Q9UQL6 1/20 0.31
FFAR1 O14842 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14720237 0.92 FASN (0.61) FASNKDM1AGSK3BCHRNA7GPBAR1
SCHEMBL14720222 0.92 FASN (0.56) FASNKDM1AGSK3BCHRNA7GPBAR1
SCHEMBL14720158 0.90 FASN (0.64) FASNKDM1AGSK3BCHRNA7GPBAR1
SCHEMBL14720427 0.89 FASN (0.61) FASNKDM1AGSK3BCHRNA7GPBAR1
SCHEMBL14720097 0.87 FASN (0.60) FASNKDM1AGSK3BCHRNA7GPBAR1
SCHEMBL14720164 0.87 FASN (0.62) FASNKDM1AGSK3BCHRNA7GPBAR1
SCHEMBL14729648 0.86 FASN (0.64) FASNKDM1AGSK3BCHRNA7
SCHEMBL14720232 0.85 FASN (0.59) FASNKDM1AGSK3BCHRNA7GPBAR1
SCHEMBL14720418 0.85 FASN (0.59) FASNKDM1AGSK3BCHRNA7GPBAR1
SCHEMBL14720306 0.85 FASN (0.58) FASNKDM1AGSK3BCHRNA7MGLL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2744333-B1 FATTY ACID SYNTHASE INHIBITORS GLAXOSMITHKLINE IP NO 2 LTD (GB) 2016-10-05 EP claimed