Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK6 | Q13882 | 5/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.47 |
| ▸ | AURKA | O14965 | 10/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407681 | 0.85 | NPC1 (0.52) | PTK6ERBB2AURKANPC1RAB9A | |
| SCHEMBL18106978 | 0.81 | BAZ2B (0.40) | NPC1RAB9AMEN1KMT2AEGFR | |
| SCHEMBL408109 | 0.80 | ERBB2 (0.47) | PTK6ERBB2AURKAALDH1A1 | |
| SCHEMBL404730 | 0.78 | ERBB2 (0.47) | PTK6ERBB2AURKAMEN1KMT2A | |
| SCHEMBL408492 | 0.76 | AURKA (0.56) | AURKA | |
| SCHEMBL3707014 | 0.76 | AURKA (0.49) | PTK6ERBB2AURKAEGFRMAPT | |
| SCHEMBL18106977 | 0.72 | LIMK2 (0.43) | NPC1RAB9AMEN1KMT2AEGFR | |
| SCHEMBL18106968 | 0.70 | MAPT (0.47) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL406603 | 0.70 | AURKA (0.50) | AURKA | |
| SCHEMBL18106972 | 0.70 | MAPT (0.43) | RAB9AMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367822-B1 | TRICYCLIC AZAINDOLES | MERCK PATENT GMBH (DE) | 2016-10-05 | — | — | EP | claimed |