Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.76 |
| ▸ | FLT1 | P17948 | 4/20 | 0.76 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.76 |
| ▸ | FLT4 | P35916 | 1/20 | 0.76 |
| ▸ | FLT3 | P36888 | 1/20 | 0.76 |
| ▸ | MERTK | Q12866 | 1/20 | 0.76 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.76 |
| ▸ | RET | P07949 | 3/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29413031 | 1.00 | KDR (0.76) | KDRFLT1FGFR1FLT4FLT3 | |
| SCHEMBL14048275 | 0.92 | KDR (0.77) | KDRFLT1FGFR1FLT4FLT3 | |
| SCHEMBL4882838 | 0.90 | KDR (0.80) | KDRFLT1FGFR1FLT4FLT3 | |
| SCHEMBL15888415 | 0.89 | KDR (0.70) | KDRFLT1FGFR1FLT4FLT3 | |
| SCHEMBL14024559 | 0.88 | KDR (0.74) | KDRFLT1FGFR1FLT4FLT3 | |
| Surufatinib SCHEMBL29363337 | 0.87 | KDR (1.00) | KDRFLT1FGFR1FLT4FLT3 | |
| Surufatinib SCHEMBL1822601 | 0.87 | KDR (1.00) | KDRFLT1FGFR1FLT4FLT3 | |
| Surufatinib SCHEMBL29366533 | 0.87 | KDR (1.00) | KDRFLT1FGFR1FLT4FLT3 | |
| SCHEMBL15510414 | 0.85 | KDR (0.68) | KDRFLT1FGFR1FLT4FLT3 | |
| SCHEMBL28690029 | 0.84 | KDR (0.87) | KDRFLT1FGFR1FLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2504331-A1 | COMPOUND, CERTAIN NOVEL FORMS THEREOF, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR PREPARATION AND USE | Hutchison Medipharma Limited (CN) | 2012-10-03 | — | — | EP | disclosed |
| WO-2011060746-A1 | COMPOUND, CERTAIN NOVEL FORMS THEREOF, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR PREPARATION AND USE | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-05-26 | — | — | WO | disclosed |