Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 9/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131825 | 0.89 | FGFR1 (0.58) | FGFR3FGFR1FGFR4FGFR2KCNH2 | |
| SCHEMBL18134020 | 0.86 | FGFR3 (0.52) | FGFR3FGFR1FGFR4INSRALK | |
| SCHEMBL18131707 | 0.86 | FGFR4 (0.56) | FGFR3FGFR1FGFR4FGFR2KCNH2 | |
| SCHEMBL18131735 | 0.82 | FGFR4 (0.70) | FGFR3FGFR1FGFR4FGFR2 | |
| SCHEMBL15244202 | 0.82 | FGFR3 (0.61) | FGFR3FGFR1FGFR4FGFR2KCNH2 | |
| SCHEMBL15728627 | 0.78 | FGFR3 (0.65) | FGFR3FGFR1FGFR4FGFR2KCNH2 | |
| SCHEMBL18132818 | 0.77 | FGFR3 (0.56) | FGFR3FGFR1FGFR4FGFR2KCNH2 | |
| SCHEMBL15728503 | 0.77 | FGFR3 (0.70) | FGFR3FGFR1FGFR4FGFR2KCNH2 | |
| SCHEMBL15728559 | 0.76 | FGFR3 (0.71) | FGFR3FGFR1FGFR4FGFR2KCNH2 | |
| SCHEMBL18912651 | 0.76 | FGFR3 (0.81) | FGFR3FGFR1FGFR4FGFR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |