Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 10/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131827 | 1.00 | FGFR4 (0.46) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131714 | 0.89 | FGFR4 (0.47) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131713 | 0.89 | FGFR4 (0.47) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21386671 | 0.82 | FGFR4 (0.64) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131690 | 0.80 | FGFR4 (0.50) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21756608 | 0.79 | FGFR4 (0.39) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21386670 | 0.79 | FGFR4 (0.47) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131701 | 0.77 | TSHR (0.43) | CYP3A4CYP2C19ALDH1A1MAPTMEN1 | |
| SCHEMBL18131743 | 0.76 | TSHR (0.42) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21756495 | 0.76 | FGFR4 (0.66) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |