Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | GPER1 | Q99527 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | GPR183 | P32249 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24203419 | 0.92 | NPC1 (0.61) | NPC1RAB9AGPER1L3MBTL1GPR183 | |
| SCHEMBL12722689 | 0.81 | GPER1 (0.60) | NPC1RAB9AGPER1L3MBTL1GPR183 | |
| SCHEMBL916068 | 0.81 | GPER1 (0.62) | NPC1RAB9AGPER1L3MBTL1GPR183 | |
| SCHEMBL916308 | 0.81 | GPER1 (0.60) | NPC1RAB9AGPER1L3MBTL1GPR183 | |
| SCHEMBL12942704 | 0.79 | GPER1 (0.57) | NPC1RAB9AGPER1L3MBTL1GPR183 | |
| SCHEMBL15107072 | 0.78 | GPER1 (0.58) | NPC1RAB9AGPER1L3MBTL1GPR183 | |
| SCHEMBL12700925 | 0.78 | MAPT (0.71) | NPC1RAB9AGPER1L3MBTL1GPR183 | |
| SCHEMBL916446 | 0.78 | MAPT (0.70) | NPC1RAB9AGPER1L3MBTL1GPR183 | |
| SCHEMBL12700906 | 0.78 | MAPT (0.78) | NPC1RAB9AGPER1L3MBTL1GPR183 | |
| SCHEMBL12722304 | 0.77 | GPER1 (0.54) | NPC1RAB9AGPER1L3MBTL1GPR183 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11987576-B2 | Compositions and methods for decreasing, or preventing or reversing gain of, skin pigmentation in a mammalian subject | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2024-05-21 | — | — | US | disclosed |
| US-11236074-B2 | Compositions and methods for decreasing, or preventing or reversing gain of, skin pigmentation in a mammalian subject | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2022-02-01 | — | — | US | disclosed |
| US-20220017497-A1 | COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT | UNIV PENNSYLVANIA (US) | 2022-01-20 | — | — | US | disclosed |
| US-20180354935-A1 | COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT | UNIV PENNSYLVANIA (US) | 2018-12-13 | — | — | US | disclosed |
| EP-3280410-A2 | COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT | The Trustees Of The University Of Pennsylvania (US) | 2018-02-14 | — | — | EP | disclosed |
| WO-2016164460-A2 | COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2016-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180354935-A1 | COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT | MC1R, GPER1, NR2E3 | NPC1 2127/4885RAB9A 3763/4885GPER1 2/4885 |
| US-11987576-B2 | Compositions and methods for decreasing, or preventing or reversing gain of, skin pigmentation in a mammalian subject | MC1R, GPER1, NR2E3 | NPC1 2127/4885RAB9A 3763/4885GPER1 2/4885 |
| US-11236074-B2 | Compositions and methods for decreasing, or preventing or reversing gain of, skin pigmentation in a mammalian subject | MC1R, GPER1, NR2E3 | NPC1 2127/4885RAB9A 3763/4885GPER1 2/4885 |
| US-20220017497-A1 | COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT | MC1R, GPER1, NR2E3 | NPC1 2127/4885RAB9A 3763/4885GPER1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.