Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 18/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18133990 | 0.87 | FGFR3 (0.50) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL21386642 | 0.85 | FGFR4 (0.68) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL20094066 | 0.81 | FGFR4 (0.49) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL18131741 | 0.79 | FGFR4 (0.78) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL15434003 | 0.79 | FGFR4 (0.65) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL15413122 | 0.77 | FGFR4 (0.46) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL21756489 | 0.77 | FGFR4 (0.47) | FGFR4FGFR1FGFR3FGFR2 | |
| SCHEMBL21756587 | 0.76 | FGFR4 (0.46) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL21386622 | 0.74 | FGFR4 (0.65) | FGFR4FGFR1FGFR3FGFR2CYP3A4 | |
| SCHEMBL15434045 | 0.73 | FGFR1 (0.67) | FGFR4FGFR1FGFR3FGFR2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |