Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15412383 | 0.89 | TSHR (0.45) | TSHRSMN1; SMN2HSD17B10KCNMA1TDP1 | |
| SCHEMBL18131712 | 0.89 | TSHR (0.45) | TSHRSMN1; SMN2HSD17B10KCNMA1TDP1 | |
| SCHEMBL30466489 | 0.89 | TSHR (0.45) | TSHRSMN1; SMN2HSD17B10KCNMA1TDP1 | |
| SCHEMBL21386640 | 0.88 | SMN1; SMN2 (0.50) | TSHRSMN1; SMN2HSD17B10KCNMA1TDP1 | |
| SCHEMBL18131701 | 0.86 | TSHR (0.43) | TSHRSMN1; SMN2HSD17B10KCNMA1TDP1 | |
| SCHEMBL18131743 | 0.85 | TSHR (0.42) | TSHRSMN1; SMN2HSD17B10KCNMA1TDP1 | |
| SCHEMBL15413168 | 0.78 | FGFR4 (0.60) | TSHRSMN1; SMN2KCNMA1KMT2AMAPT | |
| SCHEMBL28492231 | 0.77 | SMN1; SMN2 (0.45) | TSHRSMN1; SMN2HSD17B10KCNMA1TDP1 | |
| SCHEMBL27143115 | 0.77 | TSHR (0.45) | TSHRSMN1; SMN2HSD17B10KCNMA1TDP1 | |
| SCHEMBL16665294 | 0.77 | TSHR (0.42) | TSHRSMN1; SMN2HSD17B10KCNMA1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |