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SCHEMBL18134041

SCHEMBL18134041

C=CC(=O)Nc1ccccc1Nc1ncc(OCc2c(F)c(OC)cc(OC)c2F)cn1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ FGFR4 P22455 20/20 1.00
▸ FGFR1 P11362 12/20 1.00
▸ FGFR2 P21802 2/20 0.79
▸ FGFR3 P22607 2/20 0.79
▸ CYP3A4 P08684 2/20 0.79
▸ CYP2C9 P11712 2/20 0.79
▸ CYP2C19 P33261 2/20 0.79
▸ CYP2D6 P10635 1/20 0.79

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18131734 0.90 FGFR4 (0.87) FGFR4FGFR1FGFR2FGFR3CYP3A4
SCHEMBL18131721 0.89 FGFR4 (0.85) FGFR4FGFR1FGFR2FGFR3CYP3A4
SCHEMBL18131773 0.89 FGFR4 (0.80) FGFR4FGFR1FGFR2FGFR3CYP3A4
SCHEMBL28566310 0.89 FGFR4 (1.00) FGFR4FGFR1FGFR2FGFR3CYP3A4
SCHEMBL18131722 0.88 FGFR4 (1.00) FGFR4FGFR1FGFR2FGFR3CYP3A4
SCHEMBL18131831 0.87 FGFR4 (0.84) FGFR4FGFR1FGFR2FGFR3CYP3A4
SCHEMBL18131729 0.86 FGFR4 (0.76) FGFR4FGFR1FGFR2FGFR3CYP3A4
SCHEMBL18131788 0.83 FGFR4 (0.71) FGFR4FGFR1FGFR2FGFR3CYP3A4
SCHEMBL18131781 0.83 FGFR4 (0.71) FGFR4FGFR1FGFR2FGFR3CYP3A4
SCHEMBL20093934 0.83 FGFR4 (0.89) FGFR4FGFR1FGFR2FGFR3CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016164703-A1 FGFR4 INHIBITORS EISAI R & D MANAGEMENT CO., LTD. (JP) 2016-10-13 — — WO disclosed
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