Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UNG | P13051 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.37 |
| ▸ | TRIM33 | Q9UPN9 | 2/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | NAT1 | P18440 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895414 | 0.82 | UNG (0.56) | UNGSRCALDH1A1TRIM24TRIM33 | |
| SCHEMBL9291451 | 0.75 | UNG (0.60) | UNGSRCALDH1A1TRIM24TRIM33 | |
| SCHEMBL29952577 | 0.74 | UNG (0.46) | UNGALDH1A1TRIM24TRIM33SLC7A5 | |
| SCHEMBL20364486 | 0.73 | TDP1 (0.44) | ALDH1A1TDP1MAPTSMN1; SMN2TSHR | |
| SCHEMBL13455430 | 0.73 | UNG (0.61) | UNGSRCALDH1A1TRIM24TRIM33 | |
| SCHEMBL23782567 | 0.72 | UNG (0.44) | UNGALDH1A1POLBSMN1; SMN2HPGD | |
| SCHEMBL15156564 | 0.72 | CRBN (0.53) | UNGALDH1A1POLB | |
| SCHEMBL19737184 | 0.72 | UNG (0.60) | UNGSRCALDH1A1TRIM24TRIM33 | |
| SCHEMBL15197913 | 0.71 | UNG (0.59) | UNGSRCALDH1A1TRIM24TRIM33 | |
| SCHEMBL31487534 | 0.71 | SLC7A5 (0.48) | UNGALDH1A1SLC7A5HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016161960-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE, LTD. (KY) | 2016-10-13 | — | — | WO | disclosed |