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SCHEMBL18152285

SCHEMBL18152285

CC(C)(C)OC(=O)N1CC[C@H](Oc2ccc(NC(=O)c3ccc(O[C@H]4CCN(C(=O)OC(C)(C)C)C4)c(-c4ccc(F)c(F)c4)c3)cc2-c2ccc(F)nc2)C1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BCL9 O00512 20/20 0.65
▸ CTNNB1 P35222 20/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18152358 0.93 BCL9 (0.64) BCL9CTNNB1
SCHEMBL18152317 0.90 BCL9 (0.65) BCL9CTNNB1
SCHEMBL18165168 0.90 BCL9 (0.57) BCL9CTNNB1
SCHEMBL18152315 0.90 BCL9 (0.64) BCL9CTNNB1
SCHEMBL18152552 0.89 CTNNB1 (0.54) BCL9CTNNB1
SCHEMBL18165188 0.89 CTNNB1 (0.54) BCL9CTNNB1
SCHEMBL18152497 0.88 CTNNB1 (0.67) BCL9CTNNB1
SCHEMBL18152304 0.88 BCL9 (0.66) BCL9CTNNB1
SCHEMBL18152506 0.88 CTNNB1 (0.66) BCL9CTNNB1
SCHEMBL18152399 0.88 CTNNB1 (0.66) BCL9CTNNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016168524-A1 SUBSTITUTED N-([1,1'-BIPHENYL]-3-YL)-[1,1'-BIPHENYL]-3-CARBOXAMIDE ANALOGS AS INHIBITORS FOR BETA-CATENIN/B-CELL LYMPHOMA 9 INTERACTIONS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2016-10-20 — — WO disclosed
WO-2016168524-A1 SUBSTITUTED N-([1,1'-BIPHENYL]-3-YL)-[1,1'-BIPHENYL]-3-CARBOXAMIDE ANALOGS AS INHIBITORS FOR BETA-CATENIN/B-CELL LYMPHOMA 9 INTERACTIONS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2016-10-20 — — WO disclosed