SCHEMBL18152565

SCHEMBL18152565

N#Cc1ccc(-c2cc(NC(=O)c3ccc(OC4CCNC4)c(-c4ccc(F)c(F)c4)c3)ccc2OC2CCNC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 20/20 1.00
BCL9 O00512 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18152564 1.00 CTNNB1 (1.00) CTNNB1BCL9
SCHEMBL18165155 0.93 CTNNB1 (0.98) CTNNB1BCL9
SCHEMBL20021914 0.93 BCL9 (0.86) CTNNB1BCL9
SCHEMBL18152567 0.93 BCL9 (1.00) CTNNB1BCL9
SCHEMBL18152566 0.93 BCL9 (1.00) CTNNB1BCL9
SCHEMBL18165154 0.91 CTNNB1 (1.00) CTNNB1BCL9
SCHEMBL18165156 0.91 CTNNB1 (1.00) CTNNB1BCL9
SCHEMBL18165157 0.91 CTNNB1 (1.00) CTNNB1BCL9
SCHEMBL18165152 0.91 CTNNB1 (1.00) CTNNB1BCL9
SCHEMBL18164661 0.91 CTNNB1 (1.00) CTNNB1BCL9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016168524-A1 SUBSTITUTED N-([1,1'-BIPHENYL]-3-YL)-[1,1'-BIPHENYL]-3-CARBOXAMIDE ANALOGS AS INHIBITORS FOR BETA-CATENIN/B-CELL LYMPHOMA 9 INTERACTIONS UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) 2016-10-20 WO disclosed