Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.59 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.59 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.59 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20010859 | 0.92 | KRAS (0.59) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL20010853 | 0.92 | KRAS (0.49) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18153431 | 0.90 | KRAS (0.47) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18164044 | 0.89 | KRAS (0.60) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18164042 | 0.88 | KRAS (0.59) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL20010858 | 0.87 | KRAS (0.60) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18164049 | 0.86 | KRAS (0.59) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18164048 | 0.83 | KRAS (0.58) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18164056 | 0.83 | KRAS (0.64) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL20010863 | 0.82 | KRAS (0.60) | KRASEGFRHMOX2CRYZVAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283462-B1 | FUSED-TRICYCLIC INHIBITORS OF KRAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC (US) | 2020-12-02 | — | — | EP | disclosed |
| EP-3283462-B1 | FUSED-TRICYCLIC INHIBITORS OF KRAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC (US) | 2020-12-02 | — | — | EP | disclosed |
| US-10428064-B2 | Fused-tricyclic inhibitors of KRAS and methods of use thereof | ARAXES PHARMA LLC (US) | 2019-10-01 | — | — | US | disclosed |
| US-10428064-B2 | Fused-tricyclic inhibitors of KRAS and methods of use thereof | ARAXES PHARMA LLC (US) | 2019-10-01 | — | — | US | disclosed |
| US-20180086753-A1 | FUSED-TRICYCLIC INHIBITORS OF KRAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC | 2018-03-29 | — | — | US | disclosed |
| US-20180086753-A1 | FUSED-TRICYCLIC INHIBITORS OF KRAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC | 2018-03-29 | — | — | US | disclosed |
| US-20180086753-A1 | FUSED-TRICYCLIC INHIBITORS OF KRAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC | 2018-03-29 | — | — | US | disclosed |
| EP-3283462-A1 | FUSED-TRICYCLIC INHIBITORS OF KRAS AND METHODS OF USE THEREOF | Araxes Pharma LLC (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168540-A1 | FUSED-TRICYCLIC INHIBITORS OF KRAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC (US) | 2016-10-20 | — | — | WO | disclosed |
| WO-2016168540-A1 | FUSED-TRICYCLIC INHIBITORS OF KRAS AND METHODS OF USE THEREOF | ARAXES PHARMA LLC (US) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428064-B2 | Fused-tricyclic inhibitors of KRAS and methods of use thereof | KRAS, NRAS, HRAS | KRAS 1/4885EGFR 134/4885HMOX2 4696/4885 |
| US-20180086753-A1 | FUSED-TRICYCLIC INHIBITORS OF KRAS AND METHODS OF USE THEREOF | KRAS, NRAS, HRAS | KRAS 1/4885EGFR 134/4885HMOX2 4696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.