Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | FGB | P02675 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CALCRL | Q16602 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18165465 | 1.00 | CRBN (0.39) | CRBNALOX15HSD17B10HTTMEN1 | |
| SCHEMBL18144797 | 1.00 | CRBN (0.39) | CRBNALOX15HSD17B10HTTMEN1 | |
| SCHEMBL2767626 | 0.93 | CRBN (0.41) | CRBNALOX15HSD17B10HTTMEN1 | |
| SCHEMBL18145089 | 0.93 | CRBN (0.41) | CRBNALOX15HSD17B10HTTMEN1 | |
| SCHEMBL18144771 | 0.93 | CRBN (0.41) | CRBNALOX15HSD17B10HTTMEN1 | |
| SCHEMBL21123789 | 0.92 | CALCRL (0.42) | CRBNALOX15HSD17B10HTTMEN1 | |
| SCHEMBL21123556 | 0.92 | CALCRL (0.42) | CRBNALOX15HSD17B10HTTMEN1 | |
| SCHEMBL19718133 | 0.92 | CALCRL (0.42) | CRBNALOX15HSD17B10HTTMEN1 | |
| SCHEMBL18159342 | 0.88 | CRBN (0.41) | CRBNALOX15HSD17B10HTTMEN1 | |
| SCHEMBL18148486 | 0.88 | CRBN (0.41) | CRBNALOX15HSD17B10HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9630922-B2 | 3-spiro-7-hydroxamic acid tetralins as HDAC inhibitors | FORMA THERAPEUTICS, INC. (US) | 2017-04-25 | — | — | US | disclosed |
| WO-2016168660-A1 | 3-SPIRO-7-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | WO | disclosed |