Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFB2 | P61812 | 1/20 | 0.74 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.44 |
| ▸ | MTOR | P42345 | 7/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | CBFB | Q13951 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18155029 | 0.90 | TGFB2 (0.87) | TGFB2LRRK2PIK3CAMTORPIK3CG | |
| SCHEMBL18164072 | 0.90 | TGFB2 (0.71) | TGFB2LRRK2BRD4PDGFRBFGFR1 | |
| Hydrochloric Acid SCHEMBL18155058 | 0.90 | TGFB2 (0.85) | TGFB2LRRK2PIK3CAMTORPIK3CG | |
| SCHEMBL20048525 | 0.90 | TGFB2 (0.71) | TGFB2LRRK2BRD4PDGFRBFGFR1 | |
| SCHEMBL18155081 | 0.89 | TGFB2 (0.70) | TGFB2LRRK2BRD4PDGFRBFGFR1 | |
| Hydrochloric Acid SCHEMBL21456789 | 0.88 | TGFB2 (0.69) | TGFB2LRRK2BRD4PDGFRBFGFR1 | |
| SCHEMBL18155108 | 0.87 | TGFB2 (0.81) | TGFB2 | |
| SCHEMBL18155044 | 0.86 | TGFB2 (0.67) | TGFB2BRD4PDGFRBFGFR1FLT1 | |
| SCHEMBL18155051 | 0.86 | TGFB2 (0.55) | TGFB2PIK3CAMTORPIK3CDBRD4 | |
| SCHEMBL18155075 | 0.86 | TGFB2 (0.66) | TGFB2LRRK2PIK3CAMTORBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283475-B1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-10-16 | — | — | EP | claimed |
| EP-3283475-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-21 | — | — | EP | claimed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | claimed |
| EP-3283475-B1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-10-16 | — | — | EP | disclosed |
| EP-3283475-B1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-10-16 | — | — | EP | disclosed |
| US-10179777-B2 | 3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives | MERCK PATENT GMBH (DE) | 2019-01-15 | — | — | US | disclosed |
| US-20180099947-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2018-04-12 | — | — | US | disclosed |
| EP-3283475-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10179777-B2 | 3-(1H-benzimidazol-2-yl)-1H-pyridin-2-one derivatives | ALK, ABL2, ACVR1 | TGFB2 267/4885LRRK2 2558/4885PIK3CA 845/4885 |
| US-20180099947-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | ALK, ABL2, ACVR1 | TGFB2 267/4885LRRK2 2558/4885PIK3CA 845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.