Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFB2 | P61812 | 1/20 | 0.64 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 6/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL18155112 | 0.94 | TGFB2 (0.58) | TGFB2PARP1RPS6KA3METPIM1 | |
| SCHEMBL18155060 | 0.93 | TGFB2 (0.64) | TGFB2PARP1RPS6KA3METPIM1 | |
| SCHEMBL18155087 | 0.90 | TGFB2 (0.61) | TGFB2PARP1RPS6KA3METPIM1 | |
| SCHEMBL18155083 | 0.90 | TGFB2 (0.64) | TGFB2PARP1RPS6KA3METPIM1 | |
| SCHEMBL18155032 | 0.87 | TGFB2 (0.72) | TGFB2PARP1METPIM1PIM3 | |
| SCHEMBL18155059 | 0.86 | TGFB2 (0.63) | TGFB2PARP1RPS6KA3METPIM1 | |
| SCHEMBL18155029 | 0.85 | TGFB2 (0.87) | TGFB2PARP1PIM1PIM3PIM2 | |
| Hydrochloric Acid SCHEMBL18155058 | 0.84 | TGFB2 (0.85) | TGFB2PARP1PIM1PIM3PIM2 | |
| SCHEMBL18155117 | 0.84 | TGFB2 (0.53) | TGFB2PARP1RPS6KA3METPIM2 | |
| SCHEMBL18155108 | 0.82 | TGFB2 (0.81) | TGFB2PARP1PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283475-B1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-10-16 | — | — | EP | claimed |
| EP-3283475-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | Merck Patent GmbH (DE) | 2018-02-21 | — | — | EP | claimed |
| WO-2016165808-A1 | 3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRIDIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-10-20 | — | — | WO | claimed |