Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 16/20 | 0.63 |
| ▸ | PARP1 | P09874 | 3/20 | 0.63 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16616797 | 0.82 | TNKS (0.63) | TNKSPARP1OPRM1OPRK1KDR | |
| SCHEMBL16616339 | 0.79 | TNKS (0.78) | TNKSPARP1 | |
| SCHEMBL15775242 | 0.78 | TNKS (0.83) | TNKSPARP1 | |
| SCHEMBL16625125 | 0.78 | TNKS (1.00) | TNKSPARP1 | |
| Hydrochloric Acid SCHEMBL15775374 | 0.77 | TNKS (0.81) | TNKSPARP1 | |
| SCHEMBL15775444 | 0.77 | TNKS (0.81) | TNKSPARP1 | |
| SCHEMBL16625120 | 0.76 | TNKS (0.77) | TNKSPARP1 | |
| SCHEMBL16625111 | 0.76 | TNKS (1.00) | TNKSPARP1 | |
| SCHEMBL16616588 | 0.76 | TNKS (1.00) | TNKSPARP1 | |
| SCHEMBL16625108 | 0.75 | TNKS (1.00) | TNKSPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2822656-B1 | 3-ARYL-5-SUBSTITUTED-ISOQUINOLIN-1-ONE COMPOUNDS AND THEIR THERAPEUTIC USE | CANCER RES INST ROYAL (GB) | 2016-10-19 | — | — | EP | disclosed |